Right ventricular dyssynchrony and exercise capacity in idiopathic pulmonary arterial hypertension

Autor: Beatrice Pezzuto, Daniele Berardi, Roberto Badagliacca, Gabriele Valli, Manuela Reali, Susanna Sciomer, Roberto Poscia, Carmine Dario Vizza, Elisa Giannetta, Francesco Fedele, Giovanna Manzi, Robert Naeije, Paolo Palange, Silvia Papa
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Pulmonary and Respiratory Medicine
Adult
Male
medicine.medical_specialty
Cardiac Catheterization
medicine.medical_treatment
Heart Ventricles
Hypertension
Pulmonary
Ventricular Dysfunction
Right
Cardiac index
Hemodynamics
030204 cardiovascular system & hematology
Pulmonary Artery
right ventricular dyssinchrony
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Oxygen Consumption
Afterload
Internal medicine
pulmonary hypertension
medicine
Aerobic exercise
Humans
Familial Primary Pulmonary Hypertension
effort tolerance
Ventricular dyssynchrony
Cardiac catheterization
Aged
Exercise Tolerance
business.industry
VO2 max
Middle Aged
medicine.disease
Surgery
030228 respiratory system
Echocardiography
Multivariate Analysis
Cardiology
Exercise Test
Ventricular Function
Right
Regression Analysis
Female
business
Body mass index
Popis: Survival in patients with pulmonary arterial hypertension (PAH) is determined by right ventricular (RV) function adaptation to afterload. How altered RV function impacts on exercise capacity in PAH is not exactly known.104 idiopathic PAH (IPAH) patients aged 52±14 years underwent a diagnostic right heart catheterisation, a comprehensive echocardiography including two-dimensional speckle tracking for RV dyssynchrony evaluation and a cardiopulmonary exercise test. Multivariate analyses were performed to identify independent predictors of peak oxygen uptake (peakV′O2).A first multivariate analysis of only resting haemodynamic variables identified cardiac index, right atrial (RA) pressure and pulmonary arterial compliance as independent predictors, with low predictive capacity (r2=0.31; p2=0.35; p2=0.48; pV′O2(r2=0.53; p=0.001).A comprehensive echocardiography with speckle tracking-derived assessment of the heterogeneity of RV contraction improves the prediction of aerobic exercise capacity in IPAH.
Databáze: OpenAIRE
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