Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study
| Autor: | R. Cadorniga, A. Dyas, H. H. Soep, D. Adam, J. Acar, J. Pijck, Th. Hallynck, M. Wenk, R. Wise |
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| Rok vydání: | 1983 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Antibiotics Microbial Sensitivity Tests Pharmacology Pharmacokinetics Kanamycin Tobramycin Medicine Humans Pharmacology (medical) Amikacin Bacteria business.industry Aminoglycoside Half-life Crossover study carbohydrates (lipids) Kinetics Infectious Diseases Gentamicin Gentamicins business medicine.drug Half-Life |
| Zdroj: | The Journal of antimicrobial chemotherapy. 12(4) |
| ISSN: | 0305-7453 |
| Popis: | The hypothesis that the pharmacokinetics of amikacin are more predictable than those of gentamicin or tobramycin was studied. In a three-way crossover design 58 volunteers received 7.5 mg/kg amikacin by iv infusion and either 1.5 mg/kg or 1 mg/kg gentamicin and tobramycin. The mean half-life and mean serum concentration at 1 h for each drug was determined. No consistent significant difference was found between the pharmacokinetics of amikacin and the other two drugs. |
| Databáze: | OpenAIRE |
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