Clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015-2019 in Shanghai, China
| Autor: | Dong Wei, Guo Chao Shi, Yahui Liu, Chunrong Huang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
endocrine system Cellular immunity medicine.medical_specialty China Fever animal diseases viruses Pneumonia Viral Tachypnea Gastroenterology Adenoviridae Throat Internal medicine medicine Humans Shanghai china Respiratory system Lung Retrospective Studies business.industry Incidence (epidemiology) virus diseases Retrospective cohort study General Medicine medicine.disease respiratory tract diseases Pneumonia medicine.anatomical_structure Cough medicine.symptom business |
| Zdroj: | Turkish journal of medical sciences. 52(2) |
| ISSN: | 1303-6165 |
| Popis: | Background/aim This study was to describe the clinical characteristics, chest CT image findings and potential role of T cells immunity in adenovirus positive pneumonia. Materials/methods In this retrospective study, medical records of 53 adult Adv+ patients who were admitted to the Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, from May 2015 to August 2019 were included. Presence of adenovirus and other respiratory viruses was detected using by polymerase chain reaction of throat swabs samples. Clinical features and chest computed tomography (CT) findings were compared between patients with Adv+ pneumonia and Adv+ non-pneumonia. Results The top 3 most commonly occurring symptoms in Adv+ pneumonia patients were fever (66.7%), cough (63.3%), and tachypnea (16.7%). Patients with Adv+ pneumonia showed significantly higher rates of cough and fever and longer duration of hospitalization than patients with Adv+ non-pneumonia. In the Adv+ pneumonia group, consolidation (73.3%) was the most common imaging finding on chest CT scan, and the likelihood of involvement of bilateral lobes (60%) was high. Classical conspicuous consolidation with surrounding ground-glass opacity was observed in 5 (16.6%) patients with Adv+ pneumonia. Patients with Adv+ pneumonia showed a higher inhibition of T-cell immunity than did patients with Adv+ non-pneumonia, and counts of CD3+, CD4+, and CD8+ T-cells may predict the presence of pneumonia in Adv+ patients. Conclusion With regard to Adv+ pneumonia, the most frequent symptoms were cough and fever, and the most common CT pattern was consolidation; classical CT findings such as consolidation with surrounding ground-glass opacity could also be observed. Furthermore, our data indicated the incidence of abrogated cellular immunity in patients with Adv+ pneumonia. |
| Databáze: | OpenAIRE |
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