Statics and dynamics of condensed DNA within phages and globules
| Autor: | Theo Odijk |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Models
Molecular Materials science General Mathematics Molecular Sequence Data FOS: Physical sciences General Physics and Astronomy Context (language use) Condensed Matter - Soft Condensed Matter Nucleic Acid Denaturation Quantitative Biology::Subcellular Processes Motion Structure-Activity Relationship Capsid Osmotic Pressure Coulomb Osmotic pressure Bacteriophages Computer Simulation Statics Quantitative Biology::Biomolecules Toroid Base Sequence Scattering General Engineering DNA Elasticity Polyelectrolyte Quantitative Biology Condensed Matter::Soft Condensed Matter Kinetics Reptation Torque Chemical physics FOS: Biological sciences Nucleic Acid Conformation Soft Condensed Matter (cond-mat.soft) Stress Mechanical Quantitative Biology (q-bio) |
| Zdroj: | Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences. 362:1497-1517 |
| ISSN: | 1471-2962 1364-503X |
| DOI: | 10.1098/rsta.2004.1385 |
| Popis: | Several controversial issues concerning the packing of linear DNA in bacteriophages and globules are discussed. Exact relations for the osmotic pressure, capsid pressure and loading force are derived in terms of the hole size inside phages under the assumption that the DNA globule has a uniform density. A new electrostatic model is introduced for computing the osmotic pressure of rodlike polyelectrolytes at very high concentrations. At intermediate packing, a reptation model is considered for DNA diffusing within a toroidal globule. Under tight packing conditions, a model of Coulomb sliding friction is proposed. A general discussion is given of our current understanding of the statics and dynamics of confined DNA in the context of to the following experiments: characterization of the liquid crystalline phases, X-ray scattering by phages, osmotic stress measurements, cyclization within globules and single-molecule determination ofthe loading forces. Comment: 32 pages, 5 figures, submitted to Phil.Trans.Roy.Soc.A ; special issue entitled "Mechanics of DNA", editor J.M.T.Thompson |
| Databáze: | OpenAIRE |
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