High-channel-count, high-density microelectrode array for closed-loop investigation of neuronal networks
| Autor: | Rafael Yuste, David Tsai, Esha John, Kenneth L. Shepard, Tarun Chari |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Materials science
business.industry Models Neurological Bandwidth (signal processing) Multielectrode array Electrophysiology Microelectrode Planar Hardware_GENERAL Electrode Hardware_INTEGRATEDCIRCUITS Electronic engineering Electrode array Optoelectronics business Field-programmable gate array Microelectrodes Voltage |
| Zdroj: | EMBC |
| DOI: | 10.1109/embc.2015.7320129 |
| Popis: | We present a system for large-scale electrophysiological recording and stimulation of neural tissue with a planar topology. The recording system has 65,536 electrodes arranged in a 256 × 256 grid, with 25.5 μm pitch, and covering an area approximately 42.6 mm(2). The recording chain has 8.66 μV rms input-referred noise over a 100 ~ 10k Hz bandwidth while providing up to 66 dB of voltage gain. When recording from all electrodes in the array, it is capable of 10-kHz sampling per electrode. All electrodes can also perform patterned electrical microstimulation. The system produces ~ 1 GB/s of data when recording from the full array. To handle, store, and perform nearly real-time analyses of this large data stream, we developed a framework based around Xilinx FPGAs, Intel x86 CPUs and the NVIDIA Streaming Multiprocessors to interface with the electrode array. |
| Databáze: | OpenAIRE |
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