The Novel Arylamidine T-2307 Demonstrates In Vitro and In Vivo Activity against Candida auris

Autor:	Junichi Mitsuyama, April Connell, Yoshiko Fukuda, Rosie Jaramillo, Thomas F. Patterson, Nathan P. Wiederhold, Hoja P Patterson, Laura K. Najvar, Marcos Olivo, Gabriel Catano
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine Male Antifungal Agents 030106 microbiology Amidines Improved survival Pharmacology 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine In vivo Caspofungin Drug Resistance Fungal Medicine Animals Pharmacology (medical) Experimental Therapeutics Candidiasis Invasive 030212 general & internal medicine Fluconazole Candida Kidney Mice Inbred ICR business.industry In vitro Disease Models Animal Infectious Diseases medicine.anatomical_structure chemistry Candida auris Once daily business medicine.drug
Zdroj:	Antimicrob Agents Chemother
Popis:	The in vitro and in vivo activity of the arylamidine T-2307 against Candida auris was evaluated. T-2307 demonstrated in vitro activity (MIC ranges ≤ 0.008 to 0.015 μg/ml at 50% inhibition; 0.125 to >4 μg/ml at 100% inhibition).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db36e547730c65248c216d02848e07a6 https://europepmc.org/articles/PMC7038306/ Zobrazit plný text záznamu