Spirulina and Pentoxyfilline – A Novel Approach for Treatment of Oral Submucous Fibrosis
| Autor: | Raja Lakshmi Chintamaneni, Nagalakshmi Velpula, Bhavana Sujana Mulk, Vani Chappidi, Stuti Goyal, Prasannasrinivas Deshpande |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Visual analogue scale Nausea Clinical Biochemistry lcsh:Medicine Gastroenterology Bloating Fibrosis Internal medicine medicine Burning Sensation Spirulina (genus) biology business.industry Stomach lcsh:R General Medicine medicine.disease biology.organism_classification Surgery stomatognathic diseases medicine.anatomical_structure Oral submucous fibrosis potentially malignant disorder Dentistry pentoxyfilline oral submucous fibrosis (osmf) spirulina medicine.symptom business |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 7, Iss 12, Pp 3048-3050 (2013) |
| Popis: | Background: Oral submucous fibrosis is a habit associated insidious precancerous condition of the oral cavity commonly found in Asian countries. Many treatment modalities have been attempted in treating the condition apart from steroids which have been the main stay. Hence the present study was designed to assess the efficacy of spirulina and pentoxyfilline and also to compare them in oral submucous fibrosis. Material and Methods: Fourty Patients with clinico-histological diagnosis of oral sub mucous fibrosis were selected and divided into two groups with 20 in each group by simple randomization method. Group I received Pentoxyfilline and Group II Spirulina for period of 3 months. The efficacy was assessed by parameters like mouth opening, burning sensation and tongue protrusion using vernier caliper, visual analog scale and a metric scale respectively along with the side effects. Results: Student’s t-test was applied to obtain the results. Both Pentoxyfilline and Spirulina groups showed statistically significant results (p=0.000) in all the three parameters namely mouth opening, burning sensation and tongue protrusion. On comparing both the drugs statistically insignificant results were obtained for mouth opening (p=0.35) and tongue protrusion (p=0.25) but statistically significant difference was seen in subjective parameter i.e burning sensation (p=0.04). Side effects like bloating of stomach, nausea and gastritis were noted in the pentoxyfilline group in contrast to Spirulina group. Conclusion: Newer drugs Pentoxyfilline and Spirulina showed promising results in treatment of Oral sub mucous fibrosis. Spirulina was used for the first time for treatment of Oral submucous fibrosis (OSMF) and it proved to be superior than pentoxyfilline as no side effects were observed. Also it was superior in reducing burning sensation and hence can be advised in OSMF patients suffering from severe subjective symptoms. |
| Databáze: | OpenAIRE |
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