PREDICT-juvenile-stroke: PRospective evaluation of a prediction score determining individual clinical outcome three months after ischemic stroke in young adults – a study protocol
| Autor: | Sonja Schönecker, Verena Hoffmann, Fady Albashiti, Reinhard Thasler, Marlien Hagedorn, Marie-Luise Louiset, Anna Kopczak, Jennifer Rösler, Enayatullah Baki, Silke Wunderlich, Florian Kohlmayer, Klaus Kuhn, Martin Boeker, Johannes Tünnerhoff, Sven Poli, Ulf Ziemann, Oliver Kohlbacher, Katharina Althaus, Susanne Müller, Albert Ludolph, Hans A. Kestler, Ulrich Mansmann, Marianne Dieterich, Lars Kellert |
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| Rok vydání: | 2023 |
| Předmět: |
complications [Ischemic Attack
Transient] Juvenile stroke General Medicine Prognosis diagnosis [Stroke] Three months outcome Prediction score diagnosis [Ischemic Attack Transient] Stroke complications [Ischemic Stroke] Young Adult Observational Studies as Topic Ischemic Attack Transient Predictive Value of Tests Validation Humans complications [Stroke] ddc:610 Neurology (clinical) epidemiology [Ischemic Attack Transient] epidemiology [Stroke] Aged Ischemic Stroke Retrospective Studies |
| Zdroj: | BMC neurology 23(1), 2 (2023). doi:10.1186/s12883-022-03003-7 |
| ISSN: | 1471-2377 |
| DOI: | 10.1186/s12883-022-03003-7 |
| Popis: | Background Although of high individual and socioeconomic relevance, a reliable prediction model for the prognosis of juvenile stroke (18–55 years) is missing. Therefore, the study presented in this protocol aims to prospectively validate the discriminatory power of a prediction score for the 3 months functional outcome after juvenile stroke or transient ischemic attack (TIA) that has been derived from an independent retrospective study using standard clinical workup data. Methods PREDICT-Juvenile-Stroke is a multi-centre (n = 4) prospective observational cohort study collecting standard clinical workup data and data on treatment success at 3 months after acute ischemic stroke or TIA that aims to validate a new prediction score for juvenile stroke. The prediction score has been developed upon single center retrospective analysis of 340 juvenile stroke patients. The score determines the patient’s individual probability for treatment success defined by a modified Rankin Scale (mRS) 0–2 or return to pre-stroke baseline mRS 3 months after stroke or TIA. This probability will be compared to the observed clinical outcome at 3 months using the area under the receiver operating characteristic curve. The primary endpoint is to validate the clinical potential of the new prediction score for a favourable outcome 3 months after juvenile stroke or TIA. Secondary outcomes are to determine to what extent predictive factors in juvenile stroke or TIA patients differ from those in older patients and to determine the predictive accuracy of the juvenile stroke prediction score on other clinical and paraclinical endpoints. A minimum of 430 juvenile patients ( Discussion The juvenile stroke prediction score has the potential to enable personalisation of counselling, provision of appropriate information regarding the prognosis and identification of patients who benefit from specific treatments. Trial registration The study has been registered at https://drks.de on March 31, 2022 (DRKS00024407). |
| Databáze: | OpenAIRE |
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