Small arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric acid

Autor: Ethem Kumbay, Tunay Şentürk, Aysel Aydin Kaderli, Bülent Özdemir, İbrahim Baran, Yusuf Yilmaz, Murat Fazlioglu, Ali Aydinlar
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı., Fazlıoğlu, Murat, Şentürk, Tunay, Kumbay, Ethem, Kaderli, Aysel Aydın, Yılmaz, Yusuf, Özdemir, Bülent, Baran, İbrahim, Aydınlar, Ali, K-6651-2012, AAI-6632-2021, C-1517-2017
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Coronary angiography
Male
Scoring system
Cardiac & cardiovascular systems
Angina pectoris
Coronary artery disease
Stiffness
Artery tone
chemistry.chemical_compound
Endothelial dysfunction
Middle aged
Priority journal
Angiocardiography
Plaque forming cell
Arterial elasticity
Arterial stiffness
medicine.anatomical_structure
Unstable angina pectoris
Cardiology
Female
Cardiology and Cardiovascular Medicine
Artery
Human
Risk
Adult
medicine.medical_specialty
Manometry
Major clinical study
Article
Tonometry
Association
Cardiovascular-disease
Internal medicine
medicine
Humans
Hyperuricemia
Uric Acid
Gout
Disease severity
Aged
business.industry
Serum uric acid
Marker
medicine.disease
Cardiovascular risk
Heart-disease
Elasticity
Cardiovascular system & cardiology
chemistry
Risk factors
Clinical feature
Peripheral vascular disease
Uric acid
Linear models
business
Controlled study
Uric acid blood level
Popis: Background: Arterial elasticity has been previously linked to atherosclerotic vascular disease states. Serum uric acid level has been recently associated with increased arterial stiffness, but to what extent serum uric acid reflects angiographic coronary artery status and vessel compliance remains to be established. In this study we aimed to evaluate the association of arterial elasticity indexes, serum uric acid and the presence and extent of angiographic coronary artery disease (CAD) in patients with chronic stable angina. Methods: One hundred and eight consecutive patients attending for elective coronary angiography were investigated. The severity of CAD was expressed using the Gensini score. Quantitative analysis of the arterial elasticity was performed by applanation tonometry. Serum uric acid was measured in all participants. Stepwise multiple linear regression analysis was used to identify the independent correlates of the Gensini score. Results: After adjustment for age, gender, common cardiac risk factors and cardiovascular drugs, small artery elasticity index (SAEI) (p < 0.001) and Serum uric acid (p < 0.001) were independently correlated with the severity of CAD. Stepwise multiple linear regression analysis was also used to identify independent correlates of the SAEI. Serum uric acid emerged as the only independent correlate of SAEI (P < 0.001). Conclusions: SAEI independently reflects the extent of CAD in patients with chronic stable angina. This relationship is chiefly mediated by serum uric acid. Our data add to the growing evidence that serum uric acid may be a marker of arterial stiffness and atherosclerotic burden.
Databáze: OpenAIRE
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