Soluble E-Cadherin: An Early Marker of Severity in Acute Pancreatitis
| Autor: | Avinash Sewpaul, M. Kernohan, T. K. Khoo, Richard Charnley, John A. Kirby, Jeremy French |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Article Subject medicine.drug_class lcsh:Surgery Monoclonal antibody Severity of Illness Index Gastroenterology Young Adult Elisa kit Internal medicine Severity of illness medicine Humans In patient lcsh:RC799-869 Young adult Aged Aged 80 and over Hepatology business.industry Cadherin lcsh:RD1-811 Middle Aged Cadherins medicine.disease Pancreatitis Acute Disease Acute pancreatitis Female lcsh:Diseases of the digestive system. Gastroenterology Surgery business Biomarkers Research Article |
| Zdroj: | HPB Surgery, Vol 2009 (2009) Scopus-Elsevier HPB Surgery |
| ISSN: | 1607-8462 0894-8569 |
| Popis: | Background/Aims. At present, there is no simple test for predicting severity in acute pancreatitis. We investigated the use of an assay of soluble E-cadherin (sE-cadherin).Methods. Concentrations of sE-cadherin, from 19 patients with mild acute pancreatitis, 7 patients with severe acute pancreatitis, 11 patients with other acute gastrointestinal pathologies, and 12 healthy subjects were measured using a commercially available sandwich ELISA kit based on two monoclonal antibodies specific to the extracellular fragment of human E-cadherin. Measurements were made at 12 hours or less from onset of pain and also at 24 and 48 hours after onset of pain.Results. Mean (standard deviation) concentration of sE-cadherin in patients with severe acute pancreatitis at 12 hours was 17780 ng/mL (7853), significantly higher than that of healthy volunteers 5180 ng/mL (1350), , patients with other gastrointestinal pathologies 7358 ng/mL (6655), , and also significantly higher than that of patients with mild pancreatitis, 7332 ng/mL (2843), .Discussion. Serum sE-cadherin could be an early (within 12 hours) objective marker of severity in acute pancreatitis. This molecule warrants further investigation in the form of a large multicentre trial. |
| Databáze: | OpenAIRE |
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