Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay
| Autor: | Retha R. Newbold, Elizabeth A. Wallace, Casey E. Reed, Suzanne E. Fenton, Erin P. Hines, Wendy N. Jefferson, Darlene Dixon, Alicia B. Moore, Yi Lu, Jason P. Stanko, Eugene A. Gibbs-Flournoy |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Offspring Uterus Administration Oral Mice Inbred Strains Cervix Uteri Biology Endocrine Disruptors Toxicology Article chemistry.chemical_compound Mice Uterus/Cervix Internal medicine medicine Bioassay Animals Cervix Fluorocarbons Dose-Response Relationship Drug Estradiol Low dose Organ Size medicine.anatomical_structure Endocrinology chemistry Vagina Perfluorooctanoic acid Biological Assay Female Caprylates |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 33(4) |
| ISSN: | 1873-1708 |
| Popis: | The estrogenic and antiestrogenic potential of perfluorooctanoic acid (PFOA) was assessed using an immature mouse uterotrophic assay and by histologic evaluation of the uterus, cervix and vagina following treatment. Female offspring of CD-1 dams were weaned at 18days old and assigned to groups of equal weight, and received 0, 0.01, 0.1, or 1mg PFOA/kg BW/d by gavage with or without 17-β estradiol (E(2), 500μg/kg/d) from PND 18-20 (n=8/treatment/block). At 24h after the third dose (PND 21), uteri were removed and weighed. Absolute and relative uterine weights were significantly increased in the 0.01mg/kg PFOA only group. Characteristic estrogenic changes were present in all E(2)-treated mice; however, they were minimally visible in the 0.01 PFOA only mice. These data suggest that at a low dose PFOA produces minimal histopathologic changes in the reproductive tract of immature female mice, and does not antagonize the histopathologic effects of E(2). |
| Databáze: | OpenAIRE |
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