Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration
| Autor: | Steffen Schmitz-Valckenberg, Moritz Lindner, Maximilian Pfau, Jennifer Nadal, Lukas Goerdt, Matthias Schmid, Philipp T. Möller, Frank G. Holz, Monika Fleckenstein, Sandrine H. Künzel |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Visual acuity Composite score genetic structures Context (language use) patient reported outcomes Macular Degeneration Atrophy Quality of life Ophthalmology Age related Geographic Atrophy medicine Humans vision-related quality of life Longitudinal Studies Prospective Studies Low Vision age-related macular degeneration Vision Ocular Aged Aged 80 and over business.industry Macular degeneration medicine.disease eye diseases Geographic atrophy Cross-Sectional Studies quality of life Female sense organs medicine.symptom business |
| Zdroj: | Investigative Ophthalmology & Visual Science |
| ISSN: | 1552-5783 |
| Popis: | Purpose To longitudinally evaluate vision-related quality of life (VRQoL) in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) and define its relation to visual function and structural biomarkers. Methods Patients with GA secondary to AMD were recruited in the context of the prospective, non-interventional, natural-history Directional Spread in Geographic-Atrophy study (NCT02051998). Fundus autofluorescence and infrared reflectance images were semi-automatically annotated for GA. Linear mixed-effects models were applied to investigate the association of putative determinants with the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25) VRQoL. Results A total of 87 patients with a mean age ± SD of 77.07 ± 7.49 years were included in the analysis. At baseline, median (IQR) best-corrected visual acuity (BCVA) was 0.3 (0.51) for the better eye and 0.89 (0.76) for the worse eye; 46% of the patients showed binocular and 25.3% monocular non-central GA. The VRQoL composite score was impaired: 69.96 (24.03). Sixty-six patients with a median of 2 (2) follow-up visits after 1.08 (0.78) years were examined longitudinally. In the multivariable cross-sectional analysis, predictors of the VRQoL composite score were BCVA, GA size, and low-luminance visual acuity (LLVA) for the better eye and BCVA, foveal sparing status, and LLVA for the worse eye (cross-validated R2 = 0.32). In the longitudinal analysis, a similar prediction accuracy for VRQoL was determined (cross-validated R2 = 0.28). Prediction accuracy for VRQoL did not improve when follow-up time was added as an independent variable. Conclusions Vision-related quality of life is significantly impaired in patients with GA secondary to AMD. The cross-sectional and longitudinal association of VRQoL with visual functional and structural biomarkers supports the validity of the NEI VFQ-25 VRQoL. |
| Databáze: | OpenAIRE |
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