| Autor: |
Jananee Muralidharan, Sindhu Kashyap, Poorvikha S, Mathew Jacob, Anjali Ollapally, Jyothi Idiculla, John Michael Raj, Tinku Thomas, Anura V. Kurpad |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical nutrition ESPEN. 52 |
| ISSN: |
2405-4577 |
| Popis: |
l-Arginine (l-Arg) has been shown to help reduce respiratory support requirements in coronavirus disease 2019 (COVID-19), in an Italian study. We investigated the effect of l-Arg supplementation on the reduction in respiratory support for patients with severe COVID-19 pneumonia in an Indian population.A parallel-group, triple-blinded, randomized controlled trial (RCT) was conducted on patients with severe COVID-19 pneumonia on oxygen (OWe did an intention-to-treat analysis on 74 patients who were randomized into l-Arg (n = 38) or placebo group (n = 36). There were no significant differences between the two groups in the outcomes. At end of the study, 28 patients (73.6%) in l-Arg and 26 patients (72.2%) in the placebo group were weaned off oxygen support. The median number of days to the cessation of OIn this group of patients with severe COVID-19 pneumonia, l-Arg supplementation did not show any significant difference in outcomes when compared to placebo supplementation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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