The prevalence and clinicopathological features of breast cancer patients with hepatitis B virus infection in China
| Autor: | Linjie Lu, Jianbo Huang, Lingquan Kong, He Wu, Vishnu Prasad Adhikari, Yuxian Wei, Chunxia Zhao, Qingqing Luo, Wei Dai, Kai-nan Wu, Yu-tuan Wu, Xin Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty HBsAg China Breast surgery medicine.medical_treatment Estrogen receptor medicine.disease_cause hepatitis B surface antigens Gastroenterology 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors Internal medicine medicine breast neoplasms Humans Lymph node Hepatitis B virus biology business.industry Hepatitis B medicine.disease hepatitis B infection 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Case-Control Studies Immunology biology.protein pathology epidemiology Female Antibody business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // He Wu 1 , Chunxia Zhao 1 , Vishnu Prasad Adhikari 1 , Linjie Lu 2 , Jianbo Huang 1 , Yuxian Wei 1 , Qingqing Luo 1 , Wei Dai 1 , Yutuan Wu 1 , Xin Li 1 , Kainan Wu 1 , Ling-Quan Kong 1 1 Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China 2 Department of Thyroid and Breast Surgery, Liuzhou People’s Hospital, Liuzhou 545006, Guangxi, China Correspondence to: Ling-Quan Kong, email: huihuikp@163.com Keywords: hepatitis B surface antigens, breast neoplasms, pathology, hepatitis B infection, epidemiology Received: June 06, 2016 Accepted: December 12, 2016 Published: February 13, 2017 ABSTRACT We performed a case-control study to investigate the prevalence and clinicopathological features of breast cancer patients with hepatitis B virus (HBV) infection in China. The clinical data for 2,796 female patients with newly diagnosed, primary breast cancer were evaluated. A total of 234 breast cancer patients with HBV infection (the case group; positive for hepatitis B surface antigen [HBsAg]) and 444 breast cancer patients without HBV infection (the control group; negative for HBsAg, hepatitis B surface antibody, hepatitis B envelope antigen, hepatitis B envelope antibody, and hepatitis B core antibody) were selected for study. Analysis of the clinicopathological features revealed that the metastatic axillary lymph node ratio was lower in the case group than the control group, as was the proportion of patients with pathological T stage ≥T2. No differences in the expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, p53, or Ki67 were observed between the case and control groups. These data indicate that the rate of HBV infection is high among female breast cancer patients in China, and that HBsAg-positive breast cancer patients were generally diagnosed at an earlier stage and had fewer lymph node metastases. |
| Databáze: | OpenAIRE |
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