The regulation of vascular tetrahydrobiopterin bioavailability
| Autor: | Anna Starr, Manasi Nandi, Dania Hussein |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Phenylalanine hydroxylase
Physiology Administration Oral Biological Availability Endogeny Disease Pharmacology Nitric Oxide Nitric oxide chemistry.chemical_compound Phenylketonurias medicine Animals Humans Tetrahydrobiopterin biology Phenylalanine Hydroxylase Biopterin Endotheial dysfunction Bioavailability Nitric oxide synthase chemistry Cardiovascular Diseases biology.protein Molecular Medicine Nitric Oxide Synthase Vascular function medicine.drug |
| Zdroj: | Starr, A, Hussein, D & Nandi, M 2013, ' The regulation of vascular tetrahydrobiopterin bioavailability ', VASCULAR PHARMACOLOGY, vol. 58, no. 3, pp. 219-230 . https://doi.org/10.1016/j.vph.2012.08.002 |
| ISSN: | 1879-3649 |
| DOI: | 10.1016/j.vph.2012.08.002 |
| Popis: | 6R l-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for several enzymes including phenylalanine hydroxylase and the nitric oxide synthases (NOS). Oral supplementation of BH4 has been successfully employed to treat subsets of patients with hyperphenylalaninaemia. More recently, research efforts have focussed on understanding whether BH4 supplementation may also be efficacious in cardiovascular disorders that are underpinned by reduced nitric oxide bioavailability. Whilst numerous preclinical and clinical studies have demonstrated a positive association between enhanced BH4 and vascular function, the efficacy of orally administered BH4 in human cardiovascular disease remains unclear. Furthermore, interventions that limit BH4 bioavailability may provide benefit in diseases where nitric oxide over production contributes to pathology. This review describes the pathways involved in BH4 bio-regulation and discusses other endogenous mechanisms that could be harnessed therapeutically to manipulate vascular BH4 levels. |
| Databáze: | OpenAIRE |
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