A Novel Genetic Group of Bovine Hepacivirus in Archival Serum Samples from Brazilian Cattle
| Autor: | Matheus Nunes Weber, Ernst Peterhans, D.E. Puhl, Hanspeter Stalder, Cláudio Wageck Canal, Samuel Paulo Cibulski, Mariana S da Silva |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Article Subject General Immunology and Microbiology biology Phylogenetic tree 630 Agriculture Hepatitis C virus Hepacivirus lcsh:R lcsh:Medicine Human pathogen General Medicine medicine.disease_cause biology.organism_classification Virology General Biochemistry Genetics and Molecular Biology Virus 03 medical and health sciences Flaviviridae 030104 developmental biology Phylogenetics medicine biology.protein 570 Life sciences Bovine serum albumin |
| Zdroj: | BioMed Research International, Vol 2017 (2017) Canal, Cláudio W; Weber, Matheus N; Cibulski, Samuel P; Silva, Mariana S; Puhl, Daniela E; Stalder, Hanspeter; Peterhans, Ernst (2017). A Novel Genetic Group of Bovine Hepacivirus in Archival Serum Samples from Brazilian Cattle. BioMed research international, 2017(4732520), p. 4732520. Hindawi Publishing Corporation 10.1155/2017/4732520 |
| DOI: | 10.7892/boris.112043 |
| Popis: | Hepatitis C virus (HCV) (genus Hepacivirus; family Flaviviridae) is a major human pathogen causing persistent infection and hepatic injury. Recently, emerging HCV-like viruses were described infecting wild animals, such as bats and rodents, and domestic animals, including dogs, horses, and cattle. Using degenerate primers for detecting bovine pestiviruses in a 1996 survey three bovine serum samples showed a low identity with the genus Pestivirus of the Flaviviridae family. A virus could not be isolated in cell culture. The description of bovine hepaciviruses (BovHepV) in 2015 allowed us to retrospectively identify the sequences as BovHepV, with a 88.9% nucleotide identity. In a reconstructed phylogenetic tree, the Brazilian BovHepV samples grouped within the bovine HCV-like cluster in a separated terminal node that was more closely related to the putative bovine Hepacivirus common ancestor than to bovine hepaciviruses detected in Europe and Africa. |
| Databáze: | OpenAIRE |
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