Differential association of cortical, subcortical and spinal cord damage with multiple sclerosis disability milestones: A multiparametric MRI study
| Autor: | Chiara Zecca, Alvino Bisecco, Alessandro Meani, Paola Valsasina, Gioacchino Tedeschi, Antonio Gallo, Milagros Hidalgo de la Cruz, Maria A. Rocca, Claudio Gobbi, Massimo Filippi |
|---|---|
| Přispěvatelé: | Hidalgo de la Cruz, Milagro, Valsasina, Paola, Meani, Alessandro, Gallo, Antonio, Gobbi, Claudio, Bisecco, Alvino, Tedeschi, Gioacchino, Zecca, Chiara, A Rocca, Maria, Filippi, Massimo, Rocca, Maria A |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pathology
medicine.medical_specialty Multiple Sclerosis Cord brain volumetric MRI Disease Disability Evaluation 03 medical and health sciences Multiple Sclerosis Relapsing-Remitting 0302 clinical medicine medicine Humans Gray Matter Multiparametric Magnetic Resonance Imaging 030304 developmental biology 0303 health sciences Disability business.industry Multiple sclerosis cord Brain Multiparametric MRI medicine.disease Spinal cord Magnetic Resonance Imaging medicine.anatomical_structure Spinal Cord Neurology Neurology (clinical) Atrophy business 030217 neurology & neurosurgery |
| Popis: | Background: In multiple sclerosis (MS), cortical, subcortical and infratentorial structural damage may have a differential contribution to clinical disability according to disease phases. Purpose: To determine the relative contributions of cortical, deep (D) grey matter (GM), cerebellar and cervical cord damage to MS disability milestones. Methods: Multi-centre 3T brain and cervical cord T2- and three-dimensional (3D) T1-weighted images were acquired from 198 MS patients (139 relapsing-remitting (RR) MS, 59 progressive (P) MS) and 67 healthy controls. Brain/cord lesion burden, cortical thickness (CTh), DGM and cerebellar volumetry and cord cross-sectional area (CSA) were quantified. Random forest analyses identified predictors of expanded disability status scale (EDSS) disability milestones (EDSS = 3.0, 4.0 and 6.0). Results: MS patients had widespread atrophy in all investigated compartments versus controls ( p-range: ⩽0.001–0.05). Informative determinants of EDSS = 3.0 were cord CSA, brain lesion volume, frontal CTh and thalamic and cerebellar atrophy (out-of-bag (OOB) accuracy = 0.84, p-range: ⩽0.001–0.05). EDSS = 4.0 was mainly predicted by cerebellar and cord atrophy, frontal and sensorimotor CTh and cord lesion number (OOB accuracy = 0.84, p-range: ⩽0.001–0.04). Cervical cord CSA ( p = 0.001) and cord lesion number ( p = 0.003) predicted EDSS = 6.0 (OOB accuracy = 0.77). Conclusion: Brain lesion burden, cortical and thalamic atrophy were the main determinants of EDSS = 3.0 and 4.0, while cord damage played a major contribution to EDSS = 6.0. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|