Risk factors of Peyronie's disease. What does our clinical experience show?
| Autor: | Amado Bechara, Adolfo Casabé, G. Cheliz, Walter De Bonis, H. Rey |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Endocrinology Diabetes and Metabolism Sexual Behavior Penile Induration Disease Logistic regression Diabetes Complications Endocrinology Erectile Dysfunction Risk Factors Internal medicine medicine Humans Risk factor Aged Aged 80 and over business.industry Penile Erection Case-control study Coitus Prostate Odds ratio Middle Aged medicine.disease Confidence interval Surgery Psychiatry and Mental health Erectile dysfunction Logistic Models Reproductive Medicine Case-Control Studies Peyronie's disease business Penis |
| Zdroj: | The journal of sexual medicine. 8(2) |
| ISSN: | 1743-6109 |
| Popis: | Peyronie's disease (PD) is a localized fibrosis that affects the tunica albuginea of the penis. Its origin can be associated with coital penile trauma in men with autoimmune hypersensitivity and a presumed genetic predisposition.To identify clinical and traumatic risk factors in a patient population with PD, when compared to a control group.From November 2007 to March 2010, 317 patients sought medical attention for PD. As control group, 147 consecutive patients, who came for a prostate exam, were studied. Clinical, traumatic, and sexual history of these patients was gathered. Risks factors were considered only if they had been present before the onset of PD symptoms.The International Index of Erectile Function and the International Prostate Symptoms Score. A univariate logistic regression model (chi-square) (odds ratios [ORs] and 95% confidence intervals [CI]) was used to estimate the association of risk factors with PD; and the Student's t-test was implemented for age.The mean age of patients with PD and control group was 56.7 and 58.8, respectively (P0.923). The mean evolution time of the disease was 17.7 months (2-48). Erectile dysfunction (ED) and coital trauma constituted the only two independent risk factors for PD compared to the control group (P0.05 and 0.002, respectively) with an OR of 1.5 (95% CI 1.0-2.3) and 2.69 (95% CI 1.41-5.21), respectively. Patients with ED and diabetes mellitus and with a mild-to-moderate ED also presented a higher predisposition (P=0.008 and 0.00001), with an OR of 3.64 (95% CI 1.33-10.79) and 5.58 (95% CI 3.03-10.42), respectively.Erectile dysfunction and coital trauma have proven to be independent risk factors for the development of PD. |
| Databáze: | OpenAIRE |
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