A high-performance liquid chromatographic method for the determination of stobadin pharmacokinetics in serum
| Autor: | V. Fedelesova, Z. Kállay, Štefan Bezek, Ladislav Šoltés |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Chemistry Pharmaceutical Administration Oral Biological Availability Pharmaceutical Science High-performance liquid chromatography Biological fluid Single oral dose Dogs Pharmacokinetics Stobadin dipalmitate Oral administration Animals Humans Pharmacology (medical) Chromatography High Pressure Liquid Pharmacology Chromatography Chemistry General Medicine Serum concentration Bioavailability Female Anti-Arrhythmia Agents Carbolines |
| Zdroj: | Biopharmaceutics & Drug Disposition. 12:29-35 |
| ISSN: | 1099-081X 0142-2782 |
| DOI: | 10.1002/bdd.2510120104 |
| Popis: | A high-performance liquid chromatographic method was developed to determine stobadin pharmacokinetics in dog and man. The relative bioavailability of stobadin dipalmitate compared with dihydrochloride was 46.4 per cent in dog. In man peak serum concentrations ranged from 12 to 289 ng ml-1 after a single oral dose of stobadin dipalmitate (0.79 to 2.5 mgkg-1). |
| Databáze: | OpenAIRE |
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