Herpesvirus saimiri-immortalized human T-cells support long-term, high titred replication of human immunodeficiency virus types 1 and 2

Autor:	Michelle Penny, Rod S. Daniels, Chris Atkins, Helmut Fickenscher, Cherelyn Vella
Rok vydání:	1997
Předmět:	Herpesvirus saimiri T-Lymphocytes viruses HIV Core Protein p24 Human immunodeficiency virus (HIV) Biology Cell Transformation Viral Virus Replication medicine.disease_cause Virology Virus Herpesvirus 2 Saimiriine CD4 Antigens HIV-2 HIV-1 medicine Humans Permissive Tropism Cell Line Transformed
Zdroj:	Journal of General Virology. 78:1405-1409
ISSN:	1465-2099 0022-1317
DOI:	10.1099/0022-1317-78-6-1405
Popis:	Herpesvirus saimiri strain C488 transforms human CD4+ T-lymphocytes to continuous interleukin-2-dependent growth. Unlike human T-cell lines derived from tumours or those transformed by human T-lymphotropic virus 1, herpesvirus saimiri-immortalized T-cells (HVS T-cells) retain many functions of primary activated T-lymphocytes. We have characterized the course of human immunodeficiency virus types 1 and 2 (HIV-1/-2) infection in three HVS T-cell lines. Our results confirm that HVS T-cells are highly permissive to both HIV-1/-2 prototype viruses and to poorly replicating HIV-2 strains of restricted cell tropism. However, the infection was persistently productive for up to 5 months. The down-regulation of surface CD4 molecules was delayed and virus yields significantly exceeded those obtained in T-cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db26bd470608ccedf910a5d9ce12d23d https://doi.org/10.1099/0022-1317-78-6-1405 Zobrazit plný text záznamu