Peptoids as tools and sensors
| Autor: | Adrian S. Culf |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Biophysics Nanotechnology Peptoid Sequence (biology) Biological Transport General Medicine Biosensing Techniques 010402 general chemistry 01 natural sciences Biochemistry Chemical space Catalysis 0104 chemical sciences Biomaterials chemistry.chemical_compound Peptoids chemistry Neoplasms Positron-Emission Tomography Molecule Animals Crystallization Macromolecule |
| Zdroj: | Biopolymers. 110(6) |
| ISSN: | 1097-0282 |
| Popis: | A review of molecular tools and sensors assembled on N-substituted glycine, or α-peptoid, oligomers between 2013 and November 2018 with the following sections: (a) Peptoids as crystal growth modifiers, (b) Peptoids as catalysts, (c) Ion and molecule sequestration and transport, (d) Peptoid sensors, (e) Macromolecule recognition, (f) Cellular transporters, (g) Medical imaging, (h) Future direction and (i) Summary and outlook. Peptoids are a promising class of peptide mimic making them an excellent platform for functional molecule preparation. Attributes of peptoid oligomers include: (a) the ease of precise sequence definition and mono-dispersity; (b) access to a vast chemical space within simple and repeating chemical preparative steps and (c) thermal, chemical and biological stability all lending support for their application in a number of areas, with some that have been realised to date. The peptoid tool and sensor examples selected have realised practical utility. They serve to illustrate the rapidity of new insight that can generate in many disparate areas of science and technology, enabling the quick assembly of design criteria for efficient peptoid molecular tools and sensors. |
| Databáze: | OpenAIRE |
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