Nasal mucosal histamine reactivity among teachers six years after working in a moisture-damaged school
| Autor: | J. E. Juto, S. Rudblad, Kjell Andersson, Göran Stridh, Lennart Bodin |
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| Rok vydání: | 2005 |
| Předmět: |
Nasal Provocation Tests
medicine.medical_treatment education Provocation test Mucous membrane of nose Nasal provocation test Microcirculation chemistry.chemical_compound Occupational Exposure Edema Hypersensitivity Laser-Doppler Flowmetry medicine Humans Nose Skin Tests Schools business.industry Public Health Environmental and Occupational Health Humidity Faculty Nasal Mucosa medicine.anatomical_structure chemistry Anesthesia Immunology medicine.symptom business Perfusion Histamine |
| Zdroj: | Scandinavian Journal of Work, Environment & Health. 31:52-58 |
| ISSN: | 1795-990X 0355-3140 |
| Popis: | Objectives The objective of this study was to determine whether verified increased nasal mucosal reactivity among teachers, who had been working in a school with severe moisture problems, still persisted 6 years after remedial measures had been taken. The increased nasal mucosal reactivity, measured as the mucosal swelling reaction upon histamine provocation, had earlier been shown both 1 and 3 years after the renovation. Methods Twenty-four teachers in the target school and sixteen teachers in the control school, who participated in all the investigations (1995, 1997 and 2000), answered a standardized questionnaire and underwent a nasal histamine provocation test. In addition to the registration of mucosal swelling, the microcircular reaction to histamine provocation was measured with laser-Doppler flowmetry. Results The nasal histamine reactivity among the teachers, measured as the mucosal swelling reaction, was no longer increased. However, the laser-Doppler flowmetry showed that the teachers in the target school had significantly divergent microcircular perfusion (P=0.0022) and a concentration of moving blood cells (P=0.0009) in the histamine provocation when compared with the teachers in the control school; this finding indicates more-pronounced plasma leakage and edema from the nasal mucosa. Conclusions Restored nasal histamine reactivity, measured as mucosal swelling reaction, was observed among the teachers 6 years after an obviously successful renovation of the school environment. However, changes in microcirculation indicate a remaining effect on the nasal mucosa. |
| Databáze: | OpenAIRE |
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