Aerobic bacteria associated with diabetic foot ulcers and their susceptibility pattern
| Autor: | Emmanuel Nsan, Eyam Sunday Eyam, Ofonime M. Ogba |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Bacteria medicine.drug_class Aerobic bacteria business.industry Antibiotics Erythromycin General Medicine lcsh:RL1-803 medicine.disease Diabetic foot Ciprofloxacin Antibiotic resistance Diabetic foot ulcer Internal medicine lcsh:Dermatology medicine Klebsiella pneumonia business Susceptibility pattern medicine.drug |
| Zdroj: | Biomedical Dermatology, Vol 3, Iss 1, Pp 1-6 (2019) |
| ISSN: | 2398-8460 |
| Popis: | Background Foot ulcers in diabetes mellitus subjects cause morbidity and mortality and lead to non-traumatic amputations worldwide. Knowledge of the microbial burden in the ulcers may improve patients’ care and management. Objectives This prospective study was designed to isolate, identify and carry out antibiotic susceptibility testing on bacterial isolates associated with diabetic foot ulcers among subjects in University of Calabar Teaching Hospital. Methods Subjects with diabetic foot ulcer were recruited after obtaining ethical clearance from the Research Committee and informed consent from the subjects. Samples were obtained from subjects using sterile swabs and subjected to microscopy and culture. Isolates were identified using standard bacteriological techniques. Kirby-Bauer method was used for susceptibility testing. Results Out of the 50 subjects recruited, 19 (38.1%) were males and 31 (62.0%) were females with mean age of 55.4 ± 10.1 and a minimum age of 40.0 years. All the subjects had grade 4 wounds. The study recorded 100% infection rates among subjects with 70.0% polymicrobial infections. A total of 97 isolates were obtained from the 50 subjects accounting for the average of 1.94 isolates per subject. The most prevalent isolate was Staphylococcus aureus (32 (32.9%)), while the least isolated pathogen was Klebsiella pneumonia (10 (20.4%)). Females harboured more isolates (61 (62.9%)) than males (36 (37.1%)), but infection rates were not significantly associated with gender (χ² = 15.0, p ≥ 0.05). Erythromycin was the most effective antibiotic agent (65.6%) against S. aureus while gram-negative bacteria were more susceptible to augmentin (87.5%) and ciprofloxacin (75.0%). Conclusion The multiple antibiotic resistance of the bacterial isolates calls for the need to monitor resistance. The best practice is to perform antibiotic susceptibility testing before treatment. Wounds should be evaluated for bacterial agents before treatment is instituted. Information on the mi.uction of morbidity and amputation rates on the patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink