Effect of High-Voltage Pulsed Current and Alternating Current on Macromolecular Leakage in Hamster Cheek Pouch Microcirculation
| Autor: | Dale R Fish, Frank C. Mendel, Robert Hard, Keith Taylor, Harold W. Burton |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Physical Therapy Sports Therapy and Rehabilitation Stimulation Microcirculation law.invention Capillary Permeability chemistry.chemical_compound Electricity Cheek pouch law Cricetinae medicine Animals Edema Leakage (electronics) Mesocricetus biology Chemistry biology.organism_classification Electric Stimulation Surgery Cheek Dextran Alternating current Histamine Biomedical engineering |
| Zdroj: | Physical Therapy. 77:1729-1740 |
| ISSN: | 1538-6724 0031-9023 |
| DOI: | 10.1093/ptj/77.12.1729 |
| Popis: | Electrical stimulation (ES) is supposed to affect edema formation by inhibiting macromolecular leakage from microvessels. The purpose of the study was to determine the effects of various forms of ES on macromolecular leakage from microvessels.Fifty-three hamsters were randomly assigned to one of seven groups: a control group (histamine only); groups that received histamine with cathodal high-voltage pulsed current (HVPC) at intensities of 90%, 50%, and 10% of visible motor threshold (VMT); groups that received anodal HVPC at intensities of 90% and 50% of VMT; and a group that received alternating current (AC) at 90% of VMT.Anesthetized animals were injected with fluorescein-labeled dextran. Macromolecular leakage was determined by computer analysis of fluorescence microscopy images for 5 minutes after treatment.When compared with controls, leakage was less in groups treated with cathodal HVPC at 90% and 50% of VMT and anodal HVPC at 90% of VMT.Cathodal and anodal HVPC, but not AC, curb macromolecular leakage from the microvessels of histamine-treated hamsters. [Taylor K, Mendel FC, Fish DR, et al. Effect of high-voltage pulsed current and alternating current on macromolecular leakage in hamster cheek pouch microcirculation. |
| Databáze: | OpenAIRE |
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