Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin
| Autor: | Robert D. Christensen, Archana M. Agarwal, Mari C Knudsen, Timothy M. Bahr, Jessica Meznarich, Michell Lozano-Chinga, Robin K. Ohls |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Hemolytic anemia
lcsh:R5-920 Pediatrics medicine.medical_specialty business.industry Clinical course medicine.disease End tidal Hemolysis Pathogenesis Infantile Pyknocytosis Novel Insights from Clinical Practice Darbepoetin medicine Next-generation sequencing General Earth and Planetary Sciences Good outcome lcsh:Medicine (General) business Recombinant erythropoietin General Environmental Science Hyperbilirubinemia |
| Zdroj: | Biomedicine Hub Biomedicine Hub, Vol 5, Iss 3, Pp 1-8 (2020) |
| ISSN: | 2296-6870 |
| Popis: | Infantile pyknocytosis is a rare, self-limited, hemolytic condition of unknown pathogenesis. It is diagnosed when a neonate with Coombs-negative hemolytic anemia has abundant pyknocytes and a characteristic clinical course after other hemolytic disorders has been excluded. Previous reports suggest that transfusions might be avoidable in this condition by administering recombinant erythropoietin. We cared for a patient with this disorder where we employed novel diagnostics and therapeutics. Despite these, and a good outcome free of transfusions, we continue to consider the condition to be idiopathic. |
| Databáze: | OpenAIRE |
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