Negative Association of Circulating MicroRNA-126 with High-sensitive C-reactive Protein and Vascular Cell Adhesion Molecule-1 in Patients with Coronary Artery Disease Following Percutaneous Coronary Intervention

Autor: Lulu Liu, Youyou Yan, Ya-Juan Jiang, Bin Liu, Junnan Wang, Ziyuan Guo
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Acute coronary syndrome
medicine.medical_specialty
Pathology
medicine.medical_treatment
lcsh:Medicine
Vascular Cell Adhesion Molecule-1
Enzyme-Linked Immunosorbent Assay
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
MicroRNA126
Coronary artery disease
Angina
03 medical and health sciences
0302 clinical medicine
Percutaneous Coronary Intervention
Restenosis
Internal medicine
medicine
Humans
High-sensitivity C-reactive Protein
cardiovascular diseases
Angina
Stable
Acute Coronary Syndrome
biology
business.industry
Reverse Transcriptase Polymerase Chain Reaction
lcsh:R
C-reactive protein
Percutaneous coronary intervention
General Medicine
Middle Aged
medicine.disease
Stenosis
MicroRNAs
030104 developmental biology
surgical procedures
operative
C-Reactive Protein
Conventional PCI
biology.protein
Cardiology
Female
Original Article
business
Zdroj: Chinese Medical Journal
Chinese Medical Journal, Vol 129, Iss 23, Pp 2786-2791 (2016)
ISSN: 2542-5641
Popis: Background: Percutaneous coronary intervention (PCI) causes endothelial damage, resulting in an inflammatory response with elevation of markers such as high-sensitive C-reactive protein (hs-CRP) and vascular cell adhesion molecule-1 (VCAM-1), which are associated with restenosis after PCI. Evidence suggests that microRNA-126 (miR-126) plays an important role in vascular inflammation, but its correlation with PCI-mediated inflammation has not been investigated. In this study, we investigated the effect of PCI on circulating miR-126 and inflammation markers such as hs-CRP and VCAM-1. Methods: We enrolled 130 patients with coronary artery disease (CAD) in the Second Hospital of Jilin University from October 2015 to December 2015. Among them, 82 patients with CAD, defined as at least one major epicardial vessel with >70% stenosis who planned to undergo PCI, were divided into acute coronary syndrome (ACS) group (46 patients) and stable angina (SA) group (36 patients). Forty-eight patients confirmed by coronary angiography without PCI were used as controls. The plasmas of all patients were collected prior to PCI and at 30 min, 24 h, and 72 h after PCI. The plasma VCAM-1 and hs-CRP were detected by enzyme-linked immunosorbent assay, and the miR-126 was evaluated by quantitative reverse transcription-polymerase chain reaction. Results: Plasma concentrations of hs-CRP and VCAM-1 in patients with either ACS (n = 46) or SA (n = 36) were significantly higher than in controls (n = 48) (P < 0.01) prior to PCI, and increased further at 24 h and 72 h after PCI, compared with prior PCI. Moreover, VCAM-1 was positively correlated with balloon time and pressure. In contrast, the plasma concentration of miR-126 was significantly lower in patients with CAD than in controls, and further decreased with time post-PCI. A negative correlation was observed between miR-126 and hs-CRP and VCAM-1 at 72 h after PCI. Conclusion: There was a negative correlation of miR-126 with the PCI-induced markers of inflammation such as hs-CRP and VCAM-1.
Databáze: OpenAIRE
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