Future medicinal chemists experience flow chemistry: optimization by experimental design of the limiting synthetic step to the antifungal drug econazole nitrate
| Autor: | Antimo Gioiello, Bruno Cerra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Fluid Flow and Transfer Processes
010405 organic chemistry Computer science Test data generation Organic Chemistry Synthesis optimization Antifungal drug Undergraduate laboratory practice Limiting Flow chemistry 010402 general chemistry 01 natural sciences Experimental design 0104 chemical sciences Econazole Nitrate Monobromination reaction Chemistry (miscellaneous) Biochemical engineering Continuous flow chemistry |
| Popis: | A practical experience to showcase the potential of flow technology in the synthesis optimization of drugs has been developed and carried out by fourth year undergraduate students in Pharmaceutical Chemistry and Technology (CTF) at the University of Perugia. In particular, we present an experiment aimed at optimizing the monobromination reaction of 2′,4′-dichloroacetophenone, the limiting step to the synthesis of the antifungal drug econazole nitrate. Throughout the experiment, the students learn how to integrate flow chemistry and experimental design to expedite experimental screening and reaction optimization. Moreover, the students have the possibility to exploit the use of automation to improve data generation and reduce human intervention in repetitive, expensive or hazardous experiments. |
| Databáze: | OpenAIRE |
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