Nasal carriage in Vietnamese children of Streptococcus pneumoniae resistant to multiple antimicrobial agents
| Autor: | Jeremy Farrar, Catrin Davies, John Wain, Diem Nga, Nguyen Thi Tuyet Hoa, Tran Tinh Hien, Mary Gainsborough, Christopher M. Parry, To Song Diep, Nicholas J. White, Nguyen Hoan Phu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Adolescent
medicine.drug_class Antibiotics Erythromycin Drug resistance Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Streptococcal Infections Streptococcus pneumoniae medicine Humans Pharmacology (medical) Serotyping Child Antibacterial agent Pharmacology Infant Drug Resistance Microbial Antimicrobial Drug Resistance Multiple Anti-Bacterial Agents Penicillin Multiple drug resistance Infectious Diseases Susceptibility Child Preschool Carrier State Nasal Cavity medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 44(3) |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Resistance to antimicrobial agents in Streptococcus pneumoniae is increasing rapidly in many Asian countries. There is little recent information concerning resistance levels in Vietnam. A prospective study of pneumococcal carriage in 911 urban and rural Vietnamese children, of whom 44% were nasal carriers, was performed. Carriage was more common in children P , 0.01). A total of 136 of 399 isolates (34%) had intermediate susceptibility to penicillin (MIC, 0.1 to 1 mg/liter), and 76 of 399 isolates (19%) showed resistance (MIC, >1.0 mg/liter). A total of 54 of 399 isolates (13%) had intermediate susceptibility to ceftriaxone, and 3 of 399 isolates (1%) were resistant. Penicillin resistance was 21.7 (95% confidence interval, 7.0 to 67.6) times more common in urban than in rural children (35 versus 2%; P , S. pneumoniae isolates were 19, 23, 14, 6, and 18. Almost half of the penicillin-resistant isolates serotyped were serotype 23, and these isolates were often multidrug resistant. This study suggests that resistance to penicillin and other antimicrobial agents is common in carriage isolates of S. pneumoniae from children in Vietnam. |
| Databáze: | OpenAIRE |
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