The Tree of Sirtuins and the Garden of Cardiovascular Youth
| Autor: | Thomas Makris, Maria E. Marketou, Ioannis Kallikazaros, Vasiliki Katsi, Leonidas Raftopoulos, Petros Nihoyannopoulos, Antonios N Pavlidis, Dimitris Tousoulis, Charalampos I. Liakos, Nikolaos Alexopoulos |
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| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
NAD metabolism Age Factors Energy metabolism Biology NAD Bioinformatics medicine.disease_cause Metabolism regulation Cardiovascular Physiological Phenomena Type ii diabetes Metabolic Diseases Biochemistry Cardiovascular Diseases medicine Animals Humans Sirtuins NAD+ kinase Energy Metabolism Cardiology and Cardiovascular Medicine Oxidative stress |
| Zdroj: | Current Vascular Pharmacology. 14:80-87 |
| ISSN: | 1570-1611 |
| Popis: | Sirtuins (SIRTs) are a class of nicotine adenine dinucleotide (NAD+)-dependent proteins which participate in numerous molecular pathways involved in various age-related human diseases, such as type II diabetes, cardiovascular (CV) diseases and cancer. They have a major role in apoptosis, inflammation, oxidative stress and metabolism regulation, traits that have a great impact on CV physiology and pathology. Their unique profile of NAD+ energy dependency makes them an appealing target for human intervention in cellular and metabolic processes. This review focuses on the recent advances of SIRTs research aiming to shed light on the emerging roles of SIRTs in the pathophysiology of CV and metabolic diseases. |
| Databáze: | OpenAIRE |
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