Pre-B Acute Lymphoblastic Leukemia in a 3-Year-Old Boy With Pre-Acute Myelogenous Leukemia Myelodysplastic Syndrome

Autor: Nanette H. Grana, Maxine J. Sutcliffe, Kenneth R. Washington, Wilfredo Chamizo, Mary M. Haag, Hans-Christoph Rossbach, Jerry L. Barbosa
Rok vydání: 1998
Předmět:
Male
Monosomy
Pathology
medicine.medical_specialty
Anemia
Chromosomes
Human
Pair 20
Pre-B Acute Lymphoblastic Leukemia
Translocation
Genetic
Immunophenotyping
Myelogenous
Fatal Outcome
Bone Marrow
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
hemic and lymphatic diseases
Acute lymphocytic leukemia
medicine
Humans
Cell Lineage
Ring Chromosomes
In Situ Hybridization
Fluorescence
Chromosome Aberrations
Acute leukemia
Anemia
Refractory
with Excess of Blasts
Chromosomes
Human
Pair 12
business.industry
Chromosomes
Human
Pair 11
Myelodysplastic syndromes
Hematology
Aneuploidy
Hematopoietic Stem Cells
medicine.disease
Leukemia
Oncology
Child
Preschool
Karyotyping
Pediatrics
Perinatology and Child Health
Disease Progression
Neoplastic Stem Cells
Chromosome Deletion
business
Chromosomes
Human
Pair 17
Zdroj: Journal of Pediatric Hematology/Oncology. 20:347-352
ISSN: 1077-4114
DOI: 10.1097/00043426-199807000-00014
Popis: Purpose: Myelodysplastic syndromes in children commonly evolve into acute leukemia, usually acute myelogenous leukemia (AML) and rarely acute lymphoblastic leukemia (ALL). The lineage of the leukemia can be predicted based on characteristic morphologic and cytogenetic findings of the marrow and peripheral blood. Patient and Methods: A 3-year-old boy had refractory anemia with excess blasts and abnormalities suggestive of pre-AML with highly unusual cytogenetic changes. ALL of pre-B phenotype developed. Results: Leukoerythroblastic anemia, pseudo Pelger-Huet neutrophils, and dysmyelopoietic hyperplasia of the marrow suggested likely early progression to AML. Complex cytogenetic abnormalities (monosomy 17 and 20, ring chromosome 11 with deletion of bands q23, and a derivative dicentric chromosome 12) were present in both the myelodysplastic marrow and the subsequent ALL. Conclusion: This case presents cytogenetic evidence of common early progenitor cell ontogeny of both malignancies (refractory anemia with excess blasts and ALL).
Databáze: OpenAIRE
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