Relationship between flow cytometric parameters, steroid receptors, and menopausal status in breast cancers
| Autor: | David D. Keightley, Allan R. Nash, Gordon A. Sarfaty, Kim T. Ow, Debra Hardy, Henry M. Abandowitz |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty medicine.medical_treatment Aneuploidy Physiology Breast Neoplasms Receptors Estradiol Biology Steroid Flow cytometry Breast cancer Internal medicine medicine Humans Receptor Interphase Aged Aged 80 and over medicine.diagnostic_test Incidence (epidemiology) General Medicine DNA Middle Aged medicine.disease Flow Cytometry Prognosis Nuclear DNA Endocrinology Oncology Receptors Estrogen Female Menopause Human breast |
| Zdroj: | Oncology. 44(1) |
| ISSN: | 0030-2414 |
| Popis: | Of 163 human breast cancers examined, 68% contained detectable aneuploid populations, whilst 32% had apparently normal DNA distributions. A slightly higher incidence of aneuploidy was observed in pre-menopausal patients (83%) than in post-menopausal patients (66%). Also, pre-menopausal patients had slightly higher proportions of S-phase or cycling (S + G2 + M) cells. Estradiol receptor negative (ER-) tumours from post-menopausal patients were found to have the lowest incidence of aneuploidy (59%) and ER- tumours from pre-menopausal patients the highest (91%). There were no significant differences in the proportions of cycling nuclei when receptor status and menopausal status were considered. A weak relationship is shown to exist between flow cytometric data and two common prognostic indicators of breast cancer, namely receptor status and menopausal status. |
| Databáze: | OpenAIRE |
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