Stimulation of Kaposi's sarcoma-associated herpesvirus viremia during hematopoietic stem cell mobilization with filgrastim
| Autor: | Thomas B. Campbell, Robert T. Schooley, James M. Neid |
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| Rok vydání: | 2004 |
| Předmět: |
Filgrastim
viruses Viremia HIV Infections medicine.disease_cause Virus Replication Herpesviridae Virus Granulocyte Colony-Stimulating Factor medicine Gammaherpesvirinae Humans Kaposi's sarcoma-associated herpesvirus Sarcoma Kaposi Hematopoietic Stem Cell Mobilization biology virus diseases Hematology biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Virology Recombinant Proteins Granulocyte colony-stimulating factor DNA Viral Herpesvirus 8 Human HIV-1 RNA Viral medicine.drug |
| Zdroj: | American journal of hematology. 77(4) |
| ISSN: | 0361-8609 |
| Popis: | The effects of hematopoietic stem cell (HSC) mobilization on Kaposi's sarcoma-associated herpesvirus (KSHV) were evaluated in three KSHV and human immunodeficiency virus type 1 co-infected subjects. KSHV DNA was not detected in purified CD34+ cell preparations from the period of filgrastim treatment. However, two of 3 subjects had transiently increased cell-free plasma KSHV DNA during filgrastim treatment. Peak plasma KSHV DNA (2,600 and 4,300 copies/mL) occurred on day 4 and declined to below the limit of detection by day 7. These findings suggest that, although CD34+ cell preparations do not have evidence of KSHV infection, HSC mobilization may stimulate KSHV replication in other cellular compartments that contribute to KSHV viremia. Am. J. Hematol. 77:410–412, 2004. © 2004 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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