Arena-Idb: a platform to build human non-coding RNA interaction networks

Autor: Flavio Licciulli, Rosalba Giugno, Giorgio De Caro, Nicola Bombieri, Giorgio Constantino, Sabino Liuni, Vincenzo Bonnici, Domenica D'Elia
Rok vydání: 2018
Předmět:
Zdroj: BMC Bioinformatics, Vol 19, Iss S10, Pp 25-38 (2018)
BMC Bioinformatics
BMC bioinformatics 19 (2018): 231–244. doi:10.1186/s12859-018-2298-8
info:cnr-pdr/source/autori:Bonnici V1, De Caro G2, Constantino G1, Liuni S2, D'Elia D2, Bombieri N1, Licciulli F2, Giugno R1./titolo:Arena-Idb: a platform to build human non-coding RNA interaction networks/doi:10.1186%2Fs12859-018-2298-8/rivista:BMC bioinformatics/anno:2018/pagina_da:231/pagina_a:244/intervallo_pagine:231–244/volume:19
ISSN: 1471-2105
DOI: 10.1186/s12859-018-2298-8
Popis: Background High throughput technologies have provided the scientific community an unprecedented opportunity for large-scale analysis of genomes. Non-coding RNAs (ncRNAs), for a long time believed to be non-functional, are emerging as one of the most important and large family of gene regulators and key elements for genome maintenance. Functional studies have been able to assign to ncRNAs a wide spectrum of functions in primary biological processes, and for this reason they are assuming a growing importance as a potential new family of cancer therapeutic targets. Nevertheless, the number of functionally characterized ncRNAs is still too poor if compared to the number of new discovered ncRNAs. Thus platforms able to merge information from available resources addressing data integration issues are necessary and still insufficient to elucidate ncRNAs biological roles. Results In this paper, we describe a platform called Arena-Idb for the retrieval of comprehensive and non-redundant annotated ncRNAs interactions. Arena-Idb provides a framework for network reconstruction of ncRNA heterogeneous interactions (i.e., with other type of molecules) and relationships with human diseases which guide the integration of data, extracted from different sources, via mapping of entities and minimization of ambiguity. Conclusions Arena-Idb provides a schema and a visualization system to integrate ncRNA interactions that assists in discovering ncRNA functions through the extraction of heterogeneous interaction networks. The Arena-Idb is available at http://arenaidb.ba.itb.cnr.it
Databáze: OpenAIRE
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