Solid-phase synthesis of benzisothiazolones as serine protease inhibitors
| Autor: | Rita L. Civiello, Kuo-Long Yu, Nicholas A. Meanwell, Daniel G.M. Roberts, Steven M. Seiler |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Serine Proteinase Inhibitors
Tertiary amine Carboxylic acid Clinical Biochemistry Serine Protease Inhibitors Pharmaceutical Science Alkylation Biochemistry Chemical synthesis Chymases Solid-phase synthesis Drug Discovery Humans Mast Cells Molecular Biology chemistry.chemical_classification biology Serine Endopeptidases Organic Chemistry Thiazoles Enzyme chemistry Enzyme inhibitor biology.protein Molecular Medicine Tryptases |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 9:663-666 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(99)00078-5 |
| Popis: | An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxide has been developed. An example using this procedure for preparation of a library of human mast cell tryptase inhibitors is described. |
| Databáze: | OpenAIRE |
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