Prognostic significance of neutrophil‐to‐lymphocyte ratio in HPV status era for oropharyngeal cancer
| Autor: | Emilio Minatel, Emanuela Vaccher, Matteo Pepa, Sara Gandini, Ombretta Alessandro, Roberto Orecchia, Barbara Alicja Jereczek-Fossa, Simone Giovanni Gugliandolo, Marta Tagliabue, Antonino De Paoli, Daniela Alterio, A. Caroli, Jerry Polesel, Vittorio Giacomarra, Damaris Patricia Rojas, Giovanni Franchin, Giuseppe Fanetti, C. Francia, Carlo Gobitti, Anna Starzyńska, A. Revelant, Maria Cossu Rocca, Valentina Lupato, Giulia Marvaso, Mohssen Ansarin |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Neutrophils 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Lymphocytes Progression-free survival Stage (cooking) Neutrophil to lymphocyte ratio General Dentistry Retrospective Studies Cancer staging business.industry Papillomavirus Infections fungi Induction chemotherapy Cancer Retrospective cohort study 030206 dentistry Prognosis medicine.disease Oropharyngeal Neoplasms stomatognathic diseases Otorhinolaryngology 030220 oncology & carcinogenesis business Chemoradiotherapy |
| Zdroj: | Oral Diseases. 26:1384-1392 |
| ISSN: | 1601-0825 1354-523X |
| DOI: | 10.1111/odi.13366 |
| Popis: | AIM To evaluate the role of baseline neutrophil-to-lymphocyte ratio (NLR) as prognostic marker in squamous cell carcinoma of the oropharynx (OPC) treated with definitive chemoradiotherapy (CRT) in the era of HPV status. PATIENTS AND METHODS A retrospective analysis of 125 patients (pts) affected with locally advanced OPC was performed. Inclusion criteria were age >18 years, stage III or IV (TNM 7th ed.) and definitive CRT. Haematological marker for their independent role as prognostic biomarkers for progression-free survival (PFS) and overall survival (OS). Logistic models were used to assess the association with downstage in TNM 8th ed. RESULTS Seventy-seven (61.6%) pts had HPV/p16 + related OPC. Therapeutic choice consisted in sequential and concurrent CRT. Median follow-up was 50 months. A value of NLR ≥3 was associated with poorer OS. Two-year OS was 91% and 81% in pts with NLR |
| Databáze: | OpenAIRE |
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