Osimertinib Administration as the Primary Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy for Brain Metastasis of De Novo T790M-positive Lung Cancer
| Autor: | Tomoko Tajiri, Susumu Noguchi, Takakazu Sugita, Sadao Horikawa, Satoshi Terashita, Hiroaki Kawachi, Tatsuyoshi Ikeue, Akari Fukao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Lung Neoplasms
Case Report T790M Carcinoma Non-Small-Cell Lung Internal Medicine medicine Humans brain metastasis Osimertinib Epidermal growth factor receptor Lung cancer Protein Kinase Inhibitors Aged Acrylamides Aniline Compounds Lung medicine.diagnostic_test biology Brain Neoplasms business.industry de novo EGFR T790M Magnetic resonance imaging DNA Neoplasm General Medicine medicine.disease Magnetic Resonance Imaging primary EGFR-TKI therapy respiratory tract diseases ErbB Receptors lung cancer medicine.anatomical_structure osimertinib Mutation Cancer research biology.protein Adenocarcinoma Female business Brain metastasis |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | A 69-year-old woman underwent left upper lobectomy for left upper lobe lung adenocarcinoma. She later perceived a left visual field defect, and a brain metastasis was detected on head magnetic resonance imaging (MRI). Epidermal growth factor receptor (EGFR) testing identified two separate EGFR mutations: an L858R mutation in exon 21 and a de novo T790M mutation in exon 20. Treatment with osimertinib was started. After one month, head MRI showed that the brain metastasis had shrunk, and the visual field defect had also improved. In this case, first-line osimertinib was effective for treating brain metastasis of de novo T790M-positive lung cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|