Microwave-Enhanced Copper-Catalyzed N-Arylation of Free and Protected Amino Acids in Water
| Autor: | Svenja Roettger, Mats Larhed, Per J. R. Sjoeberg |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
Spectrometry Mass Electrospray Ionization Chemistry Electrospray ionization Aryl Water General Medicine General Chemistry Mass spectrometry Xanthoproteic reaction Catalysis Amino acid Solvent chemistry.chemical_compound Copper catalyzed Organic chemistry Amino Acids Microwaves Racemization Copper Microwave |
| Zdroj: | Journal of Combinatorial Chemistry. 9:204-209 |
| ISSN: | 1520-4774 1520-4766 |
| DOI: | 10.1021/cc060150r |
| Popis: | A microwave-enhanced copper-catalyzed protocol for N-arylation using water as the solvent is reported. This fast transformation allows the reaction between various amino acids or amino acid esters and a diverse set of substituted aryl bromides in less than 40 min, affording good yields of non-protected N-arylated amino acids with only minor racemization (6% or less). In addition, online ESI-MS and MS/MS analysis were used to "fish-out" an anionic Cu-containing amino acid complex directly from an ongoing N-arylation reaction. |
| Databáze: | OpenAIRE |
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