CpG Island Methylator Phenotype May Predict Poor Overall Survival of Patients with Stage IV Colorectal Cancer
| Autor: | Kun-Huei Yeh, Li Hui Tseng, Been-Ren Lin, Liang-In Lin, Yu-Lin Lin, Kuo-Hsing Chen, Jin-Tung Liang, Jia-Huei Tsai, Ann-Lii Cheng, Jau-Yu Liau |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Proto-Oncogene Proteins B-raf Oncology Cancer Research medicine.medical_specialty Stage IV Colorectal Cancer Multivariate analysis Colorectal cancer Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Overall survival Humans In patient 030212 general & internal medicine Stage (cooking) neoplasms Aged Neoplasm Staging CpG Island Methylator Phenotype business.industry General Medicine DNA Methylation Middle Aged Prognosis medicine.disease digestive system diseases Survival Rate 030220 oncology & carcinogenesis Mutation CpG Islands Female Microsatellite Instability Colorectal Neoplasms Stage iv business |
| Zdroj: | Oncology. 96:156-163 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | Objective: We aimed to study the prognostic role of CpG island methylator phenotype (CIMP) in patients with different stages of colorectal cancer (CRC). Material and Methods: We analyzed CIMP in stage I–IV CRC specimens from patients who were diagnosed between 2005 and 2013. CIMP status was determined using a 5-gene MethyLight-based assay. The clinicopathologic characteristics were reviewed and the overall survival (OS) was compared between patients with CIMP-high CRC and those with CIMP-low/negative CRC. Results: Among 450 CRC specimens with successfully determined CIMP statuses, 74 (16.4%) were CIMP-high CRC. Although there was no difference in OS between patients with CIMP-high and CIMP-low/negative CRC across all stages (p = 0.4526), intriguingly, patients with stage IV CIMP-high CRC had significantly worse OS than those with stage IV CIMP-low/negative CRC (p = 0.0047). In a multivariate analysis, CIMP status remained an independent prognostic factor for overall mortality (HR = 5.60, 95% CI: 2.12–14.79, p = 0.0005) in metastatic CRC after adjusting for clinicopathologic variables and anti-cancer therapies. Conclusion: Our results revealed that the presence of CIMP independently predicts poor OS in patients with stage IV CRC. |
| Databáze: | OpenAIRE |
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