The Skin Microbiome in Atopic Dermatitis and Its Relationship to Emollients
| Autor: | Vince Bertucci, Charles Lynde, Sandy Skotnicki, Catherine Zip, Marni C. Wiseman, Anneke Andriessen, Miriam Weinstein, Catherine McCuaig |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Administration Topical Dermatology Antioxidants Dermatitis Atopic 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Microbiome Skin integumentary system Emollients business.industry Microbiota Preventive health Atopic dermatitis medicine.disease Anti-Bacterial Agents body regions 030104 developmental biology Immunology Treatment strategy Surgery business |
| Zdroj: | Journal of cutaneous medicine and surgery. 20(1) |
| ISSN: | 1203-4754 |
| Popis: | Background: Human-associated bacterial communities on the skin, skin microbiome, likely play a central role in development of immunity and protection from pathogens. In atopic patients, the skin bacterial diversity is smaller than in healthy subjects. Objective: To review treatment strategies for atopic dermatitis in Canada, taking the skin microbiome concept into account. Methods: An expert panel of 8 Canadian dermatologists explored the role of skin microbiome in clinical dermatology, specifically looking at atopic dermatitis. Results: The panel reached consensus on the following: (1) In atopic patients, the skin microbiome of lesional atopic skin is different from nonlesional skin in adjacent areas. (2) Worsening atopic dermatitis and smaller bacterial diversity are strongly associated. (3) Application of emollients containing antioxidant and antibacterial components may increase microbiome diversity in atopic skin. Conclusion: The skin microbiome may be the next frontier in preventive health and may impact the approach to atopic dermatitis treatment. |
| Databáze: | OpenAIRE |
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