Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI)

Autor: Robert Goldweber, Jessica Dawlaty, Janice M. Pogoda, Michael Shoga, Xianghong Arakaki, Michael G. Harrington, Lianyang Li, Alfred N. Fonteh, Thao Tran, George Zouridakis
Rok vydání: 2018
Předmět:
Male
Critical Care and Emergency Medicine
Traumatic Brain Injury
Physiology
Social Sciences
lcsh:Medicine
Electroencephalography
Severity of Illness Index
Learning and Memory
0302 clinical medicine
Continuous performance task
Brain Injuries
Traumatic
Medicine and Health Sciences
Psychology
Attention
lcsh:Science
Trauma Medicine
Clinical Neurophysiology
Cognitive Impairment
Brain Mapping
Multidisciplinary
medicine.diagnostic_test
Cognitive Neurology
05 social sciences
Head injury
Cognition
Electrophysiology
Head Injury
Bioassays and Physiological Analysis
Memory
Short-Term
Traumatic injury
Brain Electrophysiology
Neurology
Acute Disease
Female
Traumatic Injury
Research Article
Adult
medicine.medical_specialty
Imaging Techniques
Traumatic brain injury
Cognitive Neuroscience
Neurophysiology
Neuroimaging
Research and Analysis Methods
050105 experimental psychology
Human Learning
Young Adult
03 medical and health sciences
Physical medicine and rehabilitation
medicine
Learning
Humans
0501 psychology and cognitive sciences
business.industry
Working memory
Electrophysiological Techniques
lcsh:R
Cognitive Psychology
Biology and Life Sciences
medicine.disease
Cognitive Science
lcsh:Q
Clinical Medicine
business
Neurotrauma
Neurocognitive
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 13, Iss 2, p e0188101 (2018)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0188101
Popis: Diagnosing and monitoring recovery of patients with mild traumatic brain injury (mTBI) is challenging because of the lack of objective, quantitative measures. Diagnosis is based on description of injuries often not witnessed, subtle neurocognitive symptoms, and neuropsychological testing. Since working memory (WM) is at the center of cognitive functions impaired in mTBI, this study was designed to define objective quantitative electroencephalographic (qEEG) measures of WM processing that may correlate with cognitive changes associated with acute mTBI. First-time mTBI patients and mild peripheral (limb) trauma controls without head injury were recruited from the emergency department. WM was assessed by a continuous performance task (N-back). EEG recordings were obtained during N-back testing on three occasions: within five days, two weeks, and one month after injury. Compared with controls, mTBI patients showed abnormal induced and evoked alpha activity including event-related desynchronization (ERD) and synchronization (ERS). For induced alpha power, TBI patients had excessive frontal ERD on their first and third visit. For evoked alpha, mTBI patients had lower parietal ERD/ERS at the second and third visits. These exploratory qEEG findings offer new and non-invasive candidate measures to characterize the evolution of injury over the first month, with potential to provide much-needed objective measures of brain dysfunction to diagnose and monitor the consequences of mTBI.
Databáze: OpenAIRE
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