Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?
| Autor: | G. Moreu, María José Sala-Romero, Maximino González-Jaranay, Ignacio Osoitz Leizaola-Cardesa, Antonio Aguilar-Salvatierra, Gerardo Gómez-Moreno |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Parathyroid hormone Odontología Review Bioinformatics Bone remodeling 03 medical and health sciences 0302 clinical medicine Internal medicine Vitamin D and neurology Humans Medicine Vitamin D Adverse effect General Dentistry media_common Bisphosphonate-associated osteonecrosis of the jaw Diphosphonates business.industry 030206 dentistry Bisphosphonate CIENCIAS MÉDICAS [UNESCO] medicine.disease Ciencias de la salud 030104 developmental biology Endocrinology Otorhinolaryngology Parathyroid Hormone UNESCO::CIENCIAS MÉDICAS Bisphosphonate-Associated Osteonecrosis of the Jaw Surgery Oral Surgery business Osteonecrosis of the jaw |
| Zdroj: | Leizaola-Cardesa, Ignacio-Osoitz ; Aguilar Salvatierra, Antonio ; González Jaranay, Maximino ; Moreu Burgos, Gerardo ; Sala-Romero, María-José ; Gómez Moreno, Gerardo. Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, : 236 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname Leizaola-Cardesa, Ignacio-Osoitz ; Aguilar Salvatierra, Antonio ; González Jaranay, Maximino ; Moreu Burgos, Gerardo ; Sala-Romero, María-José ; Gómez Moreno, Gerardo. Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, : 505 Medicina Oral, Patología Oral y Cirugía Bucal |
| ISSN: | 1698-6946 |
| DOI: | 10.4317/medoral.20927 |
| Popis: | It is estimated that over 190 million bisphosphonates have been prescribed worldwide. But this drug can produce adverse effects, of which osteonecrosis of the jaw and severe hypocalcemia are the most serious. It is evident that bisphosphonate administration affects multiple and diverse biochemical mediators related to bone metabolism. This review of literature investigates four basic parameters in patients treated with bisphosphonates - parathyroid hormone (PTH), bisphosphonates, vitamin D, calcium, and jaw osteonecrosis - which are fundamental for assessing bone metabolism and so the efficacy and correct use of the drug. The imbalances generated by vitamin D and calcium deficiencies, together with their multiple systemic repercussions, have been widely researched but the outcomes of these imbalances in relation to bisphosphonate administration are not well known, and some research has indicated that they may be associated with osteonecrosis of the jaw (ONJ). The present review set out to explain the functioning of bone metabolism, the importance of different chemical mediators, the imbalances produced by incorrect use of this drug, in order to forewarn against the possible relation of these parameters with ONJ, whose physiopathology remains unknown. Medical and dental clinics should keep detailed anamneses of the use of vitamin D and calcium supplements, as it is of vital importance to maintain their correct levels in blood, given that these are related to ONJ as well as other adverse effects; this procedure is also necessary in order to ensure the correct use of the drug. Key words:Bisphosphonate-related osteonecrosis of the jaw, vitamin D, parathyroid hor |
| Databáze: | OpenAIRE |
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