Gastrointestinal factors regulating lipid droplet formation in the intestine
| Autor: | David H. St-Pierre, Emile Levy, Nickolas Auclair, Lilya Melbouci |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Dietary lipid Lipid metabolism Lipid Droplets Cell Biology respiratory system Biology Lipid Metabolism Cell biology Fatty Liver 03 medical and health sciences Enterocytes 030104 developmental biology Lipotoxicity Cytoplasm Lipid droplet Chylomicrons Organelle Animals Humans lipids (amino acids peptides and proteins) Intestinal Mucosa Biogenesis Chylomicron |
| Zdroj: | Experimental Cell Research. 363:1-14 |
| ISSN: | 0014-4827 |
| Popis: | Cytoplasmic lipid droplets (CLD) are considered as neutral lipid reservoirs, which protect cells from lipotoxicity. It became clear that these fascinating dynamic organelles play a role not only in energy storage and metabolism, but also in cellular lipid and protein handling, inter-organelle communication, and signaling among diverse functions. Their dysregulation is associated with multiple disorders, including obesity, liver steatosis and cardiovascular diseases. The central aim of this review is to highlight the link between intra-enterocyte CLD dynamics and the formation of chylomicrons, the main intestinal dietary lipid vehicle, after overviewing the morphology, molecular composition, biogenesis and functions of CLD. |
| Databáze: | OpenAIRE |
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