Importance of including all pregnancy outcomes to reduce bias in epidemiologic studies of neural tube defects-Texas, 1999 to 2005
| Autor: | Tunu A. Ramadhani, Sharyn E. Parks, Mark A. Canfield |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
congenital hereditary and neonatal diseases and abnormalities Embryology medicine.medical_specialty Time Factors Adolescent Population Encephalocele Young Adult Bias Pregnancy Anencephaly Prevalence Humans Medicine Neural Tube Defects Registries Pregnancy outcomes education education.field_of_study business.industry Obstetrics Spina bifida Infant Newborn Pregnancy Outcome Neural tube General Medicine medicine.disease Texas nervous system diseases Epidemiologic Studies medicine.anatomical_structure Population Surveillance Pediatrics Perinatology and Child Health Female business Live birth Parity (mathematics) Developmental Biology |
| Zdroj: | Birth Defects Research Part A: Clinical and Molecular Teratology. 91:185-191 |
| ISSN: | 1542-0752 |
| DOI: | 10.1002/bdra.20772 |
| Popis: | BACKGROUND Neural tube defects (NTDs) often result in fetal death or elective termination; therefore, not all cases are captured in typical hospital-based surveillance. We examined sociodemographic differences among pregnancy outcomes to assess sources of bias in NTD surveillance and research. METHODS We used 1999 to 2005 Texas Birth Defects Registry data, a population-based active surveillance system, and calculated crude and adjusted prevalence ratios (aPRs). We then assessed the association of anencephaly and spina bifida with the selected characteristics, stratified by pregnancy outcomes (fetal death, elective termination, or live birth). RESULTS Data were available for 1852 NTD cases (anencephaly, 677; spina bifida, 954; and encephalocele, 221), resulting in 1211 live births, 236 fetal deaths, and 405 elective terminations. For both anencephaly and spina bifida, a significant excess of Hispanic mothers was observed among live-birth cases (aPRs = 1.2–2.4), but not among mothers experiencing other pregnancy outcomes. Mothers of anencephaly cases resulting in a non-live birth were more likely to be adolescents (aPRs = 2.4–2.7 for ages |
| Databáze: | OpenAIRE |
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