Qu-Zhuo-Tong-Bi Decoction Alleviates Gouty Arthritis by Regulating Butyrate-Producing Bacteria in Mice
| Autor: | Yu Lou, Juan Chen, Tiejuan Shao, Zhijun Xie, Chengping Wen, Xiaowei Shi, Xianghui Wen, Si-Yue Song, Zhixing He |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
SCFAs Abcg2 Qu-zhuo-tong-bi decoction Decoction Traditional Chinese medicine Pharmacology Gut flora gouty arthritis 03 medical and health sciences 0302 clinical medicine medicine Pharmacology (medical) Hyperuricemia Barrier function Original Research 030203 arthritis & rheumatology biology gut microbiota business.industry lcsh:RM1-950 biology.organism_classification medicine.disease gut homeostasis Gout 030104 developmental biology lcsh:Therapeutics. Pharmacology Butyrate-Producing Bacteria biology.protein business |
| Zdroj: | Frontiers in Pharmacology, Vol 11 (2021) Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| Popis: | Qu-zhuo-tong-bi decoction (QZTBD) is a traditional Chinese medicine prescription used to treat hyperuricemia and gout with no obvious adverse effects. However, the mechanism by which QZTBD treats gout has not been fully explored. Here, we investigated the effects of QZTBD on gouty arthritis and its therapeutic mechanism from the perspective of the gut microbiome. Our results demonstrated that QZTBD was effective for reducing serum uric acid level and attenuating paw edema and mechanical allodynia. QZTBD promoted the abundance of butyrate-producing bacteria and the production of SCFAs. Further study revealed that QZTBD restored the intestinal barrier function, modulated the expression of GPR43 and ABCG2, suppressed the activity of key glycolysis-related enzymes, and inhibited the generation of intestinal inflammatory factors. These findings suggested that QZTBD is an effective therapeutic drug for gouty arthritis. Butyrate-producing bacteria and its metabolites SCFAs might act as a potential target of QZTBD. |
| Databáze: | OpenAIRE |
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