Decreased Levels of Serum IL-34 Associated with Cognitive Impairment in Vascular Dementia
| Autor: | Yan Chen, Wei Lu, Yang Wang, Wenjing Ning, Lingxing Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Article Subject medicine.medical_treatment Lymphocyte Statistical difference Blood Pressure Gastroenterology General Biochemistry Genetics and Molecular Biology Cognition Risk Factors Internal medicine medicine Humans Cognitive Dysfunction Cognitive impairment Vascular dementia Aged Aged 80 and over General Immunology and Microbiology business.industry Dementia Vascular Interleukins Montreal Cognitive Assessment Interleukin General Medicine medicine.disease Blood pressure Cytokine medicine.anatomical_structure Case-Control Studies Cytokines Regression Analysis Medicine Female business Research Article |
| Zdroj: | BioMed Research International, Vol 2021 (2021) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Objective. Interleukin- (IL-) 34 is a new type of cytokine with neuroprotective effects discovered in recent years. However, the relationship between IL-34 and vascular dementia (VaD) has not yet been elucidated. The purpose of this study is to determine whether IL-34 is involved in cognitive impairment of VaD. Methods. From January 2017 to December 2020, 84 VaD patients and 60 healthy controls who attended Qingpu Branch of Zhongshan Hospital were prospectively included in the study. Once included in the study, demographic features of all research subjects are collected. They include age, gender, education, white blood cells (WBC), neutrophil, lymphocyte, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), triglycerides (TG), and total cholesterol (TC). Meanwhile, the Montreal Cognitive Assessment (MoCA) scale was used to assess the cognitive function of participants. The serum IL-34 level was determined by enzyme-linked immunosorbent assay (ELISA). Results. There was no significant difference between the demographic features of VaD patients and healthy controls ( p > 0.05 ). However, the serum IL-34 levels of VaD patients and healthy controls are 27.6 ± 3.9 pg / ml and 41.8 ± 6.0 pg / ml , respectively, and there is a significant statistical difference between them ( p < 0.001 ). The results of bivariate correlation analysis showed that serum IL-34 levels were significantly positively correlated with MoCA scores ( r = 0.371 , p = 0.023 ). Further regression analysis showed that IL-34 was still correlated with MoCA after adjusting for demographic features ( β = 0.276 , p = 0038 ). Conclusions. Serum IL-34 levels in VaD patients were significantly reduced, which may be an independent predictor of cognitive impairment in VaD patients. |
| Databáze: | OpenAIRE |
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