B15 Heterogeneity in East African Blacks
| Autor: | A.G. Levin, C. C. Entwistle, P. J. Hall, A. Wasunna, G. Brubaker, S. C. Knight |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Genetics
education.field_of_study Polymorphism Genetic Histocompatibility Testing Immune Sera Immunology Population Genetic Variation General Medicine Disease Human leukocyte antigen Africa Eastern Biology Biochemistry Antigen HLA Antigens Polymorphism (computer science) Genetic variation Humans Immunology and Allergy Typing education Antilymphocyte Serum |
| Zdroj: | Tissue Antigens. 16:326-332 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1980.tb00314.x |
| Popis: | One-hundred-forty-one Blacks (135 unrelated) from Kenya and Tanzania have been tissue-typed (HLA-A, B and C loci) as part of a study of host factors involved in Burkitt's lymphoma and naso-pharyngeal carcinoma. Evidence is presented for the existence in this population of several B15-related antigens which together occur with a relatively high frequency of 30% in unrelated individuals. It is likely that these variants may include the antigens SV and perhaps Bu recently defined with population frequencies of under 1% in Caucasians. In the absence of monospecific typing sera, identification of these variants may be helped by their apparently strong association with C-locus antigens in Blacks. Recognition of these B15 variants has been largely responsible for reducing the proportion of unidentified or "blank" B-locus antigens in this population to only 6%. These findings substantiate and amplify previous reports suspecting the presence of such antigens in Blacks, and should facilitate studies of possible associations of disease with HLA in these populations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text