Concurrent exercise does not prevent recognition memory deficits induced by beta-amyloid in rats
| Autor: | Felipe P. Carpes, Helen Lidiane Schmidt, Caroline Bitencourt Soares, Karine Ramires Lima, Luiza Freitas Lopes, Letícia Rossi Daré, Pâmela Billig Mello-Carpes |
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| Rok vydání: | 2021 |
| Předmět: |
Memory Disorders
Amyloid beta-Peptides Amyloid business.industry Neurodegeneration Hippocampus Experimental and Cognitive Psychology Physical exercise Disease Hippocampal formation medicine.disease Rats Behavioral Neuroscience Disease Models Animal Alzheimer Disease medicine Animals Humans Rats Wistar Beta (finance) business Neuroscience Recognition memory |
| Zdroj: | Physiologybehavior. 243 |
| ISSN: | 1873-507X |
| Popis: | Alzheimer's disease affects thousands of people worldwide. Alternatives aiming to prevent the disease or reduce its symptoms include different physical exercise configurations. Here we investigate the potential of concurrent exercise to prevent recognition memory deficits in an Alzheimer's disease-like model induced by the hippocampal beta-amyloid (Aβ) injection in Wistar rats. We demonstrate that the concurrent exercise, which included running and strength exercises performed in the same exercise session, is ineffective in preventing recognition memory deficits in the Aβ rats. Besides, higher levels of reactive oxygen species were found in the concurrent exercise group's hippocampus. The running exercise administrated alone prevented recognition memory impairments. |
| Databáze: | OpenAIRE |
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