Impact of coronary artery disease on left ventricular systolic function and geometry in hypertensive patients with left ventricular hypertrophy (the LIFE study)
| Autor: | Jens Berning, Markku S. Nieminen, Richard B. Devereux, Björn Dahlöf, Asbjørn Støylen, Michael J. Koren, Miguel Zabalgoitia |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Systole Denmark Iceland Coronary Disease Left ventricular hypertrophy Muscle hypertrophy Coronary artery disease Electrocardiography Ventricular Dysfunction Left Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Finland Aged Randomized Controlled Trials as Topic Aged 80 and over Sweden Ejection fraction medicine.diagnostic_test Norway business.industry Middle Aged medicine.disease United Kingdom United States Echocardiography Hypertension Cardiology Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American Journal of Cardiology. 88:646-650 |
| ISSN: | 0002-9149 |
| Popis: | Hypertensive patients with left ventricular (LV) hypertrophy have a higher incidence of cardiovascular events than those without it. We hypothesized that a close relation exists between clinical evidence of coronary artery disease (CAD) and alterations in LV structure and function that contribute to their higher risk. Echocardiograms were recorded in 963 hypertensive patients (mean age 66 +/- 7 years, 41% women) with electrocardiographic LV hypertrophy, and divided into 149 with and 814 without clinical (prior myocardial infarction or angina pectoris) or electrocardiographic (Minnesota codes 1.1, 1.2) evidence of CAD. Patients with CAD had larger LV internal dimensions (5.5 +/- 0.6 vs 5.2 +/- 0.5 cm), increased LV mass (136 +/- 31 vs 122 +/- 24 g/m(2), and 62.4 +/- 19.4 vs 55.5 +/- 12.1 g/m(2.7)), lower ejection fraction (58 +/- 10% vs 62 +/- 8%), higher circumferential end-systolic wall stress (cESS) (198 +/- 59 vs 181 +/- 47 kdynes/cm(2), all p |
| Databáze: | OpenAIRE |
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