K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011
| Autor: | Christine Miranda-Diaz, Robert F. Hunter-Mellado, Yelitza Ruiz-Candelaria |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
0301 basic medicine
Male Cancer Research medicine.medical_specialty Colorectal cancer Clinical Biochemistry Population Mutant Gene mutation medicine.disease_cause Gastroenterology Article Pathology and Forensic Medicine Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine Internal medicine Proto-Oncogene Proteins Medicine Humans Stage (cooking) education Aged Mutation education.field_of_study business.industry Puerto Rico Retrospective cohort study Middle Aged medicine.disease 030104 developmental biology Cross-Sectional Studies Genes ras Oncology 030220 oncology & carcinogenesis Immunology ras Proteins Female business Colorectal Neoplasms |
| Zdroj: | The International journal of biological markers. 28(4) |
| ISSN: | 1724-6008 |
| Popis: | The frequency of K-RAS mutations ranges between 30% and 48% among the Caucasian, Asian, and European populations and these mutations are predictors of response to EGFR therapies. We sought to determine the expression of K-RAS gene mutations among colorectal cancer patients in PuertoRico. A retrospective study was conducted to determine the expression of mutant K-RAS among colorectal cancer patients in Puerto Rico between April 2009 and January 2011. The mutant expression of K-RAS was found in 39% (n=195) of the Puerto Rican population, and was more common in the age group of 51-69 years (53.8%) and in males (55.4%, p>0.05). Moreover, mutant K-RAS was more commonly found in tumors of the proximal area (43.8%; p=0.03), with distant metastasis (43.3%, p=0.018), with a mucinous histotype (31.7% p>0.05), and in ulcerated tumors (38.8%, p>0.05). K-RAS mutations were observed on codon 12 (87.7%) and codon 13 (12.3%). The most frequent mutation on codon 12 was 12 ASP (39.5%), followed by 12 VAL (25.4%) that is associated with a significant decrease in overall cancer survival. The mutant expression of K-RAS in cases of rectum carcinoma was 39.5%, where the most common mutation was 12 VAL (37.5%). The frequency of K-RAS mutations in the Puerto Rican population here studied was 39% and mutant K-RAS was associated with advanced colorectal cancer stage, mucinous histotype, and ulcerated tumors. |
| Databáze: | OpenAIRE |
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