High-frequency ventilation compared to conventional positive-pressure ventilation in the treatment of hyaline membrane disease in primates
| Autor: | RICHARD E. BELL, THOMAS J. KUEHL, JACQUELINE J. COALSON, NEEL B. ACKERMAN, DONALD M. NULL, MARILYN B. ESCOBEDO, BRADLEY A. YODER, J. DEVN CORNISH, LOUDEN NALLE, ROBERT M. SKARIN, CHERYL A. CIPRIANI, MARISOL MONTES, JAMES L. ROBOTHAM, ROBERT A. DeLEMOS |
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| Rok vydání: | 1984 |
| Předmět: |
Hyaline Membrane Disease
medicine.medical_treatment Bronchi Critical Care and Intensive Care Medicine Positive-Pressure Respiration biology.animal Animals Humans Medicine Positive pressure ventilation Lung Hyaline Bronchopulmonary Dysplasia Fetus biology business.industry High-frequency ventilation Infant Newborn medicine.disease Respiration Artificial Animals Newborn Dysplasia Anesthesia Breathing Gestation business Papio Baboon |
| Zdroj: | Critical Care Medicine. 12:764-768 |
| ISSN: | 0090-3493 |
| Popis: | High-frequency ventilation (HFV) has been suggested as an alternative to conventional positive-pressure ventilation (PPV) in the treatment of infants with hyaline membrane disease (HMD). Using a previously validated primate model of HMD, 15 baboon fetuses were delivered at 75% of gestation and randomly assigned to 1 of 3 ventilator treatment groups: (a) PPV, (b) HFV delivered by an oscillator (HFO), or (c) HFV delivered by a flow interrupter (HFFI). All animals had clinical and radiographic evidence of HMD. At 96 h of life, all animals were sacrificed and clinical and pathologic findings were analyzed. During the first 10 h of the experiment, the HFO animals required higher mean proximal airway pressures than either the HFFI or PPV groups. However, both the HFFI and HFO animals had higher PaO2/PAO2 ratios than the PPV controls, suggesting earlier saccular recruitment. Thus, HFV is as effective as PPV in the treatment of HMD in baboons. Whether it will decrease the risk of bron-chopulmonary dysplasia is not known. |
| Databáze: | OpenAIRE |
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